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This "drug-like by design" philosophy has yielded a set of molecular guidelines: 9-11 amino acids, calculated lipophilicity (cLogP) 12.9, at least six N-alkylated amino acids, amide-based cyclization, and avoidance of charged residues

Side effects are minimal, though some may experience slight soreness at the injection site

In scientific studies, silymarin acts both choleretically (stimulates bile production in the liver) and chokinetically (supports gallbladder contraction and bile flow)

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Simple logistic survival regression (SR) and multiple logistic survival regression (SR) modeling for FIB-4 as a continuous variable showed an increased odds of 30-day mortality (OR 1.21